Platelet-to-Lymphocyte Ratio and Survival in Malignant Pleural Effusion

Autores de FISABIO

• Eduardo García Pachon

  Autor

• Mª José Soler Sempere

  Autor

• Lucia Zamora Molina

  Autor

• Carlos Baeza Martínez

  Autor

• Justo Javier Grau Delgado

  Autor

• Isabel Padilla Navas

  Autor

Grupos de Investigación

• GRUPO 111. SERVICIO DE NEUMOLOGÍA HOSPITAL GENERAL UNIVERSITARIO DE ELCHE

• HOSPITAL GENERAL UNIVERSITARIO DE ELCHE

Abstract

Background: Efforts have been made to search for parameters that facilitate the prediction of the 3-month survival for clinical decisions in patients with malignant pleural effusion (MPE). We sought to evaluate whether the platelet-to-lymphocyte ratio (PLR) may be a useful marker of 3-month survival in a series of consecutive patients with MPE. Methods: A total of 81 patients with MPE were included, 46 (57%) of whom were female. Twenty-six patients (32%) died during the first 3 months according to thoracentesis data. Results: The area under the receiver operating characteristics curve was 0.73 for PLR. Using a cutoff point of 158, patients with higher PLR values experienced higher mortality at 3 months (p = 0.001). Conclusions: PLR was able to successfully differentiate patients with different survival at 3 months. Outcomes of the PLR (a fast and inexpensive test) could be included among the prognostic factors able to guide the personalized management of MPE.

Keywords

• biomarker; platelet; pleural effusion; prognosis