Portal de investigación
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts
Fecha de publicación:
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Autores de FISABIO
Autores ajenos a FISABIO
- Cadman, T
- Elhakeem, A
- Vinther, JL
- Avraam, D
- Calas, L
- Cardol, M
- Charles, MA
- Corpeleijn, E
- Crozier, S
- de Castro, M
- Estarlich, M
- Fernandes, A
- Fossatti, S
- Gruszfeld, D
- Guerlich, K
- Grote, V
- Haakma, S
- Harris, JR
- Heude, B
- Huang, RC
- Ibarluzea, J
- Inskip, H
- Jaddoe, V
- Koletzko, B
- Lioret, S
- Luque, V
- Manios, Y
- Moirano, G
- Moschonis, G
- Nader, J
- Nieuwenhuijsen, M
- Andersen, AMN
- Mceachen, R
- de Moira, AP
- Popovic, M
- Roumeliotaki, T
- Salika, T
- Santa Marina, L
- Santos, S
- Serbert, S
- Tzorovili, E
- Vafeiadi, M
- Verduci, E
- Vrijheid, M
- Vrijkotte, TGM
- Welten, M
- Wright, J
- Yang, TC
- Zugna, D
- Lawlor, D
Grupos de Investigación
Abstract
International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13, and 14-17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2-3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4-7 years = 0.16 (95% CI: 0.14, 0.17), and at 8-13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.
Datos de la publicación
- ISSN/ISSNe:
- 0002-9262, 1476-6256
- Tipo:
- Article
- Páginas:
- 753-763
- DOI:
- 10.1093/aje/kwad206
- PubMed:
- 37856700
AMERICAN JOURNAL OF EPIDEMIOLOGY Oxford University Press
Citas Recibidas en Web of Science: 3
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Filiaciones
Keywords
- BMI; cohort data sharing; federated analyses; gestational diabetes; green spaces; maternal education