Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.

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Autores de FISABIO

Autores ajenos a FISABIO

  • Beaumont RN
  • Flatley C
  • Vaudel M
  • Wu X
  • Chen J
  • Moen GH
  • Skotte L
  • Helgeland Ø
  • Solé-Navais P
  • Banasik K
  • Albiñana C
  • Ronkainen J
  • Fadista J
  • Stinson SE
  • Trajanoska K
  • Wang CA
  • Westergaard D
  • Srinivasan S
  • Sánchez-Soriano C
  • Bilbao JR
  • Allard C
  • Groleau M
  • Kuulasmaa T
  • Leirer DJ
  • White F
  • Jacques PÉ
  • Cheng H
  • Hao K
  • Andreassen OA
  • Åsvold BO
  • Atalay M
  • Bhatta L
  • Bouchard L
  • Brumpton BM
  • Brunak S
  • Bybjerg-Grauholm J
  • Ebbing C
  • Elliott P
  • Engelbrechtsen L
  • Erikstrup C
  • Franks S
  • Gaillard R
  • Geller F
  • Grove J
  • Hougaard DM
  • Kajantie E
  • Morgen CS
  • Nohr EA
  • Nyegaard M
  • Palmer CNA
  • Pedersen OB
  • Early Growth Genetics (EGG) Consortium
  • Rivadeneira F
  • Sebert S
  • Shields BM
  • Stoltenberg C
  • Surakka I
  • Thørner LW
  • Ullum H
  • Vaarasmaki M
  • Vilhjalmsson BJ
  • Willer CJ
  • Lakka TA
  • Gybel-Brask D
  • Bustamante M
  • Hansen T
  • Pearson ER
  • Reynolds RM
  • Ostrowski SR
  • Pennell CE
  • Jaddoe VWV
  • Felix JF
  • Hattersley AT
  • Melbye M
  • Lawlor DA
  • Hveem K
  • Werge T
  • Nielsen HS
  • Magnus P
  • Evans DM
  • Jacobsson B
  • Järvelin MR
  • Zhang G
  • Hivert MF
  • Johansson S
  • Freathy RM
  • Feenstra B
  • Njølstad PR

Grupos de Investigación

Abstract

A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.

© 2023. The Author(s).

Datos de la publicación

ISSN/ISSNe:
1061-4036, 1546-1718

NATURE GENETICS  NATURE PUBLISHING GROUP

Tipo:
Article
Páginas:
1807-1819
PubMed:
37798380

Citas Recibidas en Web of Science: 11

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