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  3. La auténtica dimensión del colesterol-no-HDL: colesterol aterogénico.

La auténtica dimensión del colesterol-no-HDL: colesterol aterogénico.

Fecha de publicación: Fecha Ahead of Print:

Autores de FISABIO

Autores ajenos a FISABIO

  • Millán J
  • Ascaso JF
  • Blasco M
  • Brea A
  • Díaz Á
  • González-Santos P
  • Mantilla T
  • Pedro-Botet J
  • Pintó X
  • Grupo de trabajo sobre Dislipemia Aterogénica. Sociedad Española de Arterioscler

Abstract

Lowe density lipoproteins (LDL) are the causal agent of cardiovascular diseases. In practice, we identify LDL with cholesterol transported in LDL (cLDL). So, cLDL has become the major target for cardiovascular prevention. Howewer, we have progressive evidences about the role of triglycerides rich lipoproteins, particularly those very low density lipoprotein (VLDL) in promotion and progression of atherosclerosis, that leads cholesterol in VLDL and its remanents as a potential therapeutic target. This feature is particularly important and of a great magnitude, in patients with hypertiglyceridemia. We can to considere, that the non-HDL cholesterol -cLDL+cVLDL+c-remmants+Lp(a)- is the real measurement of atherogenic cholesterol. In addition, non-HDL-cholesterol do not show any variations between postprandial states. In fact, non-HDL-cholesterol should be an excellent marker of atherogenic cholesterol, and an major therapeutic target in patients with atherogenic dyslipidaemia. According with different clinical trials and with the epidemiological and mendelian studies, in patients with high cardiovascular risk, optimal level of cLDL will be under 70mg/dl, and under 100 ng/dl for non-HDL-cholesterol; and in high risk patients, 100mg/dl and 130mg/dl, respectively.

Datos de la publicación

ISSN/ISSNe:
0214-9168, 1578-1879

Clinica e Investigacion en Arteriosclerosis  ELSEVIER

Tipo:
Article
Páginas:
265-270
PubMed:
27633523

Citas Recibidas en Web of Science: 10

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Keywords

  • Atherogenic dyslipidaemia, Cardiovascular prevention, Cholesterol, Colesterol, Dislipidemia aterogénica, Prevención cardiovascular, Residual Cardiovascular Risk, Riesgo cardiovascular residual

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